Tomos Williams, Jarrod Evans and Hallam Amos have been recalled into the Wales squad as eight Cardiff Blues players are involved in the upcoming Guinness Six Nations campaign.
Head coach Wayne Pivac has made a number of changes to the Autumn Nations Cup squad, with the trio joined in the backs by regional team-mate, Josh Adams.
Scrum half, Williams, missed out on the autumn campaign due to a shoulder injury, but has been back in Cardiff Blues colours since his return in November.
Six-times capped outside half Evans returns to the international stage for the first time since last year's Six Nations, while Hallam Amos will look to add to his 22 caps, having last appeared in a try-scoring performance against New Zealand in the 2019 Rugby World Cup Bronze Final.
In the forwards, Cory Hill, Josh Navidi, Rhys Carre and Dillon Lewis all retain their spots in Pivac's squad.
A total of nine players have come through the Cardiff Blues age grade and academy pathway, with backs Callum Sheedy (Bristol Bears), Louis Rees-Zammit (Gloucester) and Leigh Halfpenny (Scarlets) all included.
“We are hugely looking forward to meeting up as a squad on Monday and to the forthcoming campaign,” said Wales head coach Pivac.
“The Guinness Six Nations is an important tournament and we have selected a squad accordingly.
“As we consistently spoke about, the autumn for us was about opportunity and development, looking ahead to RWC 2023 and it served that purpose for us.
“This campaign is different, it is tournament rugby and we are excited to get going and to play our part.
“We have picked a squad for this tournament based on form and we are excited to meet up on Monday and to get our preparation underway.”
WALES 2021 GUINNESS SIX NATIONS SQUAD
Rhys Carre (Cardiff Bues) (12 Caps)
Wyn Jones (Scarlets) (30 Caps)
Rhodri Jones (Ospreys) (17 Caps)
Elliot Dee (Dragons) (33 Caps)
Ryan Elias (Scarlets) (17 Caps)
Ken Owens (Scarlets) (77 Caps)
Leon Brown (Dragons) (12 Caps)
Tomas Francis (Exeter Chiefs) (52 Caps)
Dillon Lewis (Cardiff Blues) (28 Caps)
Jake Ball (Scarlets) (49 Caps)
Adam Beard (Ospreys) (21 Caps)
Alun Wyn Jones (Ospreys) (143 Caps)
Will Rowlands (Wasps) (5 Caps)
Cory Hill (Cardiff Blues) (29 Caps)
Dan Lydiate (Ospreys) (62 Caps)
Josh Navidi (Cardiff Blues) (24 Caps)
Aaron Wainwright (Dragons) (27 Caps)
Taulupe Faletau (Bath) (81 Caps)
Josh MacLeod (Scarlets) (*Uncapped)
Justin Tipuric (Ospreys) (80 Caps)
Gareth Davies (Scarlets) (57 Caps)
Tomos Williams (Cardiff Blues) (20 Caps)
Kieran Hardy (Scarlets) (2 Caps)
Dan Biggar (Northampton Saints) (87 Caps)
Callum Sheedy (Bristol Bears) (4 Caps)
Jarrod Evans (Cardiff Blues) (6 Caps)
Johnny Williams (Scarlets) (2 Caps)
Jonathan Davies (Scarlets) (85 Caps)
Nick Tompkins (Dragons) (8 Caps)
Owen Watkin (Ospreys) (25 Caps)
George North (Ospreys) (98 Caps)
Josh Adams (Cardiff Blues) (29 Caps)
Hallam Amos (Cardiff Blues) (22 Caps)
Louis Rees-Zammit (Gloucester) (4 Caps)
Leigh Halfpenny (Scarlets) (93 Caps)
Liam Williams (Scarlets) (67 Caps)